BOSTON–October 1, 2007–A new Joslin-led study has shown that leptin, a hormone known mainly for regulating appetite control and energy metabolism, plays a major role in islet cell growth and insulin secretion. This finding opens up new avenues for studying leptin and its role in islet cell biology, which may lead to new treatments for diabetes. This study appears in the October 2007 issue of The Journal of Clinical Investigation.

Beta glucan Lowers Blood Lipids

Beta glucan Lowers Blood Lipids

BERLIN—Barley beta-glucan reduces serum lipid levels, according to research presented in April at the First International Congress on Pre-Diabetes and Metabolic Syndrome.

In the six-week study, 76 men and 79 women with hypercholesterolemia, aged

25 to 73, completed a four-week lowfat diet prior to baseline. At the beginning of the trial, test subjects were randomly allocated to one of four treatment groups or a control group and assayed for blood lipids and other cardiovascular disease (CVD) biomarkers. During the course of the study, test groups were administered 3 g and 5 g doses of low molecular weight (LMW) or high molecular weight (HMW) barley beta-glucan (from Cargill) twice daily, in cereal and juice.

Posttreatment assessment of blood lipids and other CVD biomarkers revealed improvements in low-density lipoprotein (LDL) cholesterol, triglycerides, markers of glycemic control

(glycosylated hemoglobin, HOMA model) and a key marker of inflammation

(hs-CRP).

The researchers concluded both doses of LMW and HMW barley beta-glucan improved blood lipids over a six-week treatment period.

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Recommended Blood Glucose Numbers

What are the Right Numbers?

Depending on where you look, recommended blood glucose levels can vary. The American Diabetes Association (ADA) numbers differ from the American College of Endocrinology (ACE) guidelines. The ACE recommendations are more strict than the ADA's. How do you know which to follow? Ask your healthcare provider which goals are right for you. The table below compares the two sets of guidelines for blood glucose, blood pressure and cholesterol.

How many times a day should you check your blood glucose levels?

Checking your blood glucose levels often through out the day will help you to figure out how to keep good control. First thing in the morning before breakfast, two hours after a meal and before bed are good times to test. Other recommended times include before, during and after an exercise session, especially if it is strenuous or if you are feeling like your blood sugar may be low or high.

What is the A1C?

It's a blood test that helps you and your doctor monitor your overall glucose control.

It gives an average of the amount of glucose in your blood over a few months' time. It is usually ordered 2 to 4 times a year. If you are newly diagnosed or having trouble maintaining good day-to-day control, it may be ordered more often.

Sources:

"Checking Your Blood Glucose." American Diabetes Association. ADA. 15 Dec 2006

American Association of Clinical Endocrinologists and the American College of Endocrinology, "The AACE System of Intensive Diabetes Self-Management - 2002 Update." The American Association of Clinical Endocrinologists Medical Guidelines for the Management of Diabetes Mellitus. Endocrine Practice Vol. 8. 2002.

For more information visit: http://www.optimumdiabetics.com